
As the best preserved Spanish colonial city in Latin America, Quito’s entire old town is a UNESCO World Heritage site—though shortness of breath and headaches are common for newcomers to the city, perched at 9,350 feet (2,850 meters) in the Andes.
Photograph by Kent Kobersteen, National GeographicAt an altitude of 11,975 feet (3,650 meters), Lhasa is higher than any other city on our list. The 17th-century Potala Palace, former home of the Dalai Lama, hovers above the city like a giant Buddhist scroll.
Photograph by Michael Yamashita, National GeographicThe onetime capital of the Inca Empire—laid out in the shape of a puma—is a vivid contrast in styles. Spanish colonial churches sit side by side with the ruins of Inca temples and palaces.
Photograph by Design Pics Inc., National GeographicSet between the Kalahari and Namib Deserts, Namibia’s capital roosts on an arid 5,600-foot (1,707-meter) plateau. The isolated Afrikaner settlement grew into a thriving modern city after independence in 1990. (See eerie pictures inside a Namibian ghost town.)
A throwback to the bygone Himalaya, Thimphu flaunts medieval palaces and Buddhist festivals with drumming, dancing, and lurid masks. Its 17th-century fortified monastery houses Bhutan’s government.
Photograph by Lynsey Addario, National GeographicFounded the same year as the original Jamestown colony (1607), Santa Fe is both the highest (7,260 feet/2,213 meters) and oldest U.S. state capital. With the snowcapped Sangre de Cristo Mountains as a backdrop, this famously artsy city blends Spanish, Pueblo Indian, and modern American traditions.
Photograph by Christian Heeb, Laif, ReduxTucked into the arid mountains northwest of Mexico City, San Miguel’s bohemian vibe and pleasant highland climate has attracted artists and writers both domestic and foreign since the 1930s.
Photograph by Medford Taylor, National GeographicHost of the Winter Olympics in 1964 and 1976, Innsbruck is surrounded by skiing and snowboarding slopes. Its medieval Old Town bustles with shops and cafés, while its baroque palaces channel the long-lost Habsburg empire.
Photograph by Oliver Bolch, Anzenberger, ReduxThe queen of the Ethiopian Highlands was born of an 1886 decision by Empress Taytu Betul to establish a royal palace near sacred Mount Entoto. As base of the African Union and other organizations, Addis is the “Geneva of Africa.”
Photograph by Philippe Lissac, Godong, Corbis